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Beyond its well-established local anti-inflammatory actions, emerging evidence suggests that 5-ASA contributes to mucosal immune homeostasis through immunometabolic regulationnot as a T cellspecific drug, but via broader mechanisms including activation of the AhRIDO1 axis (256)

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Intein proteases Split inteins can be used to facilitate in vivo, site-specific protein cleavage[39] (Figure 3G)

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PMID: 195 RosenblumMDGratzIKPawJSAbbasAK